Ecotoxic response of nematodes to ivermectin, a potential anti-COVID-19 drug treatment.
Identifieur interne : 001079 ( Main/Exploration ); précédent : 001078; suivant : 001080Ecotoxic response of nematodes to ivermectin, a potential anti-COVID-19 drug treatment.
Auteurs : Naceur Essid [Tunisie] ; Mohamed Allouche [Tunisie] ; Mounira Lazzem [Tunisie] ; Abdel Halim Harrath [Arabie saoudite] ; Lamjed Mansour [Arabie saoudite] ; Saleh Alwasel [Arabie saoudite] ; Ezzeddine Mahmoudi [Tunisie] ; Hamouda Beyrem [Tunisie] ; Fehmi Boufahja [Tunisie]Source :
- Marine pollution bulletin [ 1879-3363 ] ; 2020.
Descripteurs français
- KwdFr :
- MESH :
- toxicité : Antiviraux, Ivermectine.
- traitement médicamenteux : Infections à coronavirus.
- Animaux, Betacoronavirus, Espagne, France, Humains, Italie, Mer Méditerranée, Nematoda, Pandémies, Pneumopathie virale.
- Wicri :
English descriptors
- KwdEn :
- MESH :
- chemical , toxicity : Antiviral Agents, Ivermectin.
- geographic : France, Italy, Mediterranean Sea, Spain.
- drug therapy : Coronavirus Infections.
- Animals, Betacoronavirus, Humans, Nematoda, Pandemics, Pneumonia, Viral.
Abstract
At the end of March 2020, ivermectin was confirmed as a drug for COVID-19 treatment. A significant amount of ivermectin could deposit into sediments of the semi-closed Mediterranean Sea, where three European COVID-19 epicenters are located: Italy, Spain, and France. Meiobenthic nematodes were exposed to three ivermectin doses (1.8 ng.g-1, 9 ng.g-1, and 18 ng.g-1) for 10 days. Ivermectin caused a great reduction in abundance. However, the diversity indices decreased only at high doses. Ivermectin disadvantaged the 1B-Cr-Id functional type (non-selective deposit feeders and nematodes with circular or indistinct amphids) and benefited the 2A-REL-Sp type (epistrate feeders and nematodes with rounded or elongated loop amphids). Thus, Trophic Diversity and Amphideal Diversity index values increased with sedimentary ivermectin enrichment. Large amphideal foveas were more efficient for 2A-REL-Sp nematodes to avoid ivermectin. The responses of the functional type 2A-REL-Sp and corresponding taxa predict post-COVID-19 environmental concerns and the bioaccumulation of ivermectin in seafoods.
DOI: 10.1016/j.marpolbul.2020.111375
PubMed: 32658716
PubMed Central: PMC7287431
Affiliations:
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Allouche</name><affiliation wicri:level="1"><nlm:affiliation>University of Carthage, Faculty of Sciences of Bizerte, Laboratory of Environment Biomonitoring, Coastal Ecology and Ecotoxicology Unit, 7021 Zarzouna, Tunisia.</nlm:affiliation><country xml:lang="fr">Tunisie</country><wicri:regionArea>University of Carthage, Faculty of Sciences of Bizerte, Laboratory of Environment Biomonitoring, Coastal Ecology and Ecotoxicology Unit, 7021 Zarzouna</wicri:regionArea><wicri:noRegion>7021 Zarzouna</wicri:noRegion></affiliation></author><author><name sortKey="Lazzem, Mounira" sort="Lazzem, Mounira" uniqKey="Lazzem M" first="Mounira" last="Lazzem">Mounira Lazzem</name><affiliation wicri:level="1"><nlm:affiliation>University of Carthage, Faculty of Sciences of Bizerte, Laboratory of Environment Biomonitoring, Coastal Ecology and Ecotoxicology Unit, 7021 Zarzouna, Tunisia.</nlm:affiliation><country xml:lang="fr">Tunisie</country><wicri:regionArea>University of Carthage, Faculty of Sciences of Bizerte, Laboratory of Environment Biomonitoring, Coastal Ecology and Ecotoxicology Unit, 7021 Zarzouna</wicri:regionArea><wicri:noRegion>7021 Zarzouna</wicri:noRegion></affiliation></author><author><name sortKey="Harrath, Abdel Halim" sort="Harrath, Abdel Halim" uniqKey="Harrath A" first="Abdel Halim" last="Harrath">Abdel Halim Harrath</name><affiliation wicri:level="1"><nlm:affiliation>King Saud University, Zoology Department, College of Science, Box 2455, Riyadh 11451, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>King Saud University, Zoology Department, College of Science, Box 2455, Riyadh 11451</wicri:regionArea><wicri:noRegion>Riyadh 11451</wicri:noRegion></affiliation></author><author><name sortKey="Mansour, Lamjed" sort="Mansour, Lamjed" uniqKey="Mansour L" first="Lamjed" last="Mansour">Lamjed Mansour</name><affiliation wicri:level="1"><nlm:affiliation>King Saud University, Zoology Department, College of Science, Box 2455, Riyadh 11451, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>King Saud University, Zoology Department, College of Science, Box 2455, Riyadh 11451</wicri:regionArea><wicri:noRegion>Riyadh 11451</wicri:noRegion></affiliation></author><author><name sortKey="Alwasel, Saleh" sort="Alwasel, Saleh" uniqKey="Alwasel S" first="Saleh" last="Alwasel">Saleh Alwasel</name><affiliation wicri:level="1"><nlm:affiliation>King Saud University, Zoology Department, College of Science, Box 2455, Riyadh 11451, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>King Saud University, Zoology Department, College of Science, Box 2455, Riyadh 11451</wicri:regionArea><wicri:noRegion>Riyadh 11451</wicri:noRegion></affiliation></author><author><name sortKey="Mahmoudi, Ezzeddine" sort="Mahmoudi, Ezzeddine" uniqKey="Mahmoudi E" first="Ezzeddine" last="Mahmoudi">Ezzeddine Mahmoudi</name><affiliation wicri:level="1"><nlm:affiliation>University of Carthage, Faculty of Sciences of Bizerte, Laboratory of Environment Biomonitoring, Coastal Ecology and Ecotoxicology Unit, 7021 Zarzouna, Tunisia.</nlm:affiliation><country xml:lang="fr">Tunisie</country><wicri:regionArea>University of Carthage, Faculty of Sciences of Bizerte, Laboratory of Environment Biomonitoring, Coastal Ecology and Ecotoxicology Unit, 7021 Zarzouna</wicri:regionArea><wicri:noRegion>7021 Zarzouna</wicri:noRegion></affiliation></author><author><name sortKey="Beyrem, Hamouda" sort="Beyrem, Hamouda" uniqKey="Beyrem H" first="Hamouda" last="Beyrem">Hamouda Beyrem</name><affiliation wicri:level="1"><nlm:affiliation>University of Carthage, Faculty of Sciences of Bizerte, Laboratory of Environment Biomonitoring, Coastal Ecology and Ecotoxicology Unit, 7021 Zarzouna, Tunisia.</nlm:affiliation><country xml:lang="fr">Tunisie</country><wicri:regionArea>University of Carthage, Faculty of Sciences of Bizerte, Laboratory of Environment Biomonitoring, Coastal Ecology and Ecotoxicology Unit, 7021 Zarzouna</wicri:regionArea><wicri:noRegion>7021 Zarzouna</wicri:noRegion></affiliation></author><author><name sortKey="Boufahja, Fehmi" sort="Boufahja, Fehmi" uniqKey="Boufahja F" first="Fehmi" last="Boufahja">Fehmi Boufahja</name><affiliation wicri:level="1"><nlm:affiliation>University of Carthage, Faculty of Sciences of Bizerte, Laboratory of Environment Biomonitoring, Coastal Ecology and Ecotoxicology Unit, 7021 Zarzouna, Tunisia. Electronic address: fehmiboufahja@yahoo.fr.</nlm:affiliation><country xml:lang="fr">Tunisie</country><wicri:regionArea>University of Carthage, Faculty of Sciences of Bizerte, Laboratory of Environment Biomonitoring, Coastal Ecology and Ecotoxicology Unit, 7021 Zarzouna</wicri:regionArea><wicri:noRegion>7021 Zarzouna</wicri:noRegion></affiliation></author></analytic><series><title level="j">Marine pollution bulletin</title><idno type="eISSN">1879-3363</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term><term>Antiviral Agents (toxicity)</term><term>Betacoronavirus (MeSH)</term><term>Coronavirus Infections (drug therapy)</term><term>France (MeSH)</term><term>Humans (MeSH)</term><term>Italy (MeSH)</term><term>Ivermectin (toxicity)</term><term>Mediterranean Sea (MeSH)</term><term>Nematoda (MeSH)</term><term>Pandemics (MeSH)</term><term>Pneumonia, Viral (MeSH)</term><term>Spain (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term><term>Antiviraux (toxicité)</term><term>Betacoronavirus (MeSH)</term><term>Espagne (MeSH)</term><term>France (MeSH)</term><term>Humains (MeSH)</term><term>Infections à coronavirus (traitement médicamenteux)</term><term>Italie (MeSH)</term><term>Ivermectine (toxicité)</term><term>Mer Méditerranée (MeSH)</term><term>Nematoda (MeSH)</term><term>Pandémies (MeSH)</term><term>Pneumopathie virale (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Antiviral Agents</term><term>Ivermectin</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>France</term><term>Italy</term><term>Mediterranean Sea</term><term>Spain</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="toxicité" xml:lang="fr"><term>Antiviraux</term><term>Ivermectine</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Betacoronavirus</term><term>Humans</term><term>Nematoda</term><term>Pandemics</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Betacoronavirus</term><term>Espagne</term><term>France</term><term>Humains</term><term>Italie</term><term>Mer Méditerranée</term><term>Nematoda</term><term>Pandémies</term><term>Pneumopathie virale</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>France</term><term>Italie</term><term>Espagne</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">At the end of March 2020, ivermectin was confirmed as a drug for COVID-19 treatment. A significant amount of ivermectin could deposit into sediments of the semi-closed Mediterranean Sea, where three European COVID-19 epicenters are located: Italy, Spain, and France. Meiobenthic nematodes were exposed to three ivermectin doses (1.8 ng.g<sup>-1</sup>, 9 ng.g<sup>-1</sup>, and 18 ng.g<sup>-1</sup>) for 10 days. Ivermectin caused a great reduction in abundance. However, the diversity indices decreased only at high doses. Ivermectin disadvantaged the 1B-Cr-Id functional type (non-selective deposit feeders and nematodes with circular or indistinct amphids) and benefited the 2A-REL-Sp type (epistrate feeders and nematodes with rounded or elongated loop amphids). Thus, Trophic Diversity and Amphideal Diversity index values increased with sedimentary ivermectin enrichment. Large amphideal foveas were more efficient for 2A-REL-Sp nematodes to avoid ivermectin. The responses of the functional type 2A-REL-Sp and corresponding taxa predict post-COVID-19 environmental concerns and the bioaccumulation of ivermectin in seafoods.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Automated" Owner="NLM"><PMID Version="1">32658716</PMID><DateCompleted><Year>2020</Year><Month>07</Month><Day>15</Day></DateCompleted><DateRevised><Year>2020</Year><Month>07</Month><Day>17</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1879-3363</ISSN><JournalIssue CitedMedium="Internet"><Volume>157</Volume><PubDate><Year>2020</Year><Month>Aug</Month></PubDate></JournalIssue><Title>Marine pollution bulletin</Title><ISOAbbreviation>Mar. Pollut. Bull.</ISOAbbreviation></Journal><ArticleTitle>Ecotoxic response of nematodes to ivermectin, a potential anti-COVID-19 drug treatment.</ArticleTitle><Pagination><MedlinePgn>111375</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0025-326X(20)30493-8</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.marpolbul.2020.111375</ELocationID><Abstract><AbstractText>At the end of March 2020, ivermectin was confirmed as a drug for COVID-19 treatment. A significant amount of ivermectin could deposit into sediments of the semi-closed Mediterranean Sea, where three European COVID-19 epicenters are located: Italy, Spain, and France. Meiobenthic nematodes were exposed to three ivermectin doses (1.8 ng.g<sup>-1</sup>, 9 ng.g<sup>-1</sup>, and 18 ng.g<sup>-1</sup>) for 10 days. Ivermectin caused a great reduction in abundance. However, the diversity indices decreased only at high doses. Ivermectin disadvantaged the 1B-Cr-Id functional type (non-selective deposit feeders and nematodes with circular or indistinct amphids) and benefited the 2A-REL-Sp type (epistrate feeders and nematodes with rounded or elongated loop amphids). Thus, Trophic Diversity and Amphideal Diversity index values increased with sedimentary ivermectin enrichment. Large amphideal foveas were more efficient for 2A-REL-Sp nematodes to avoid ivermectin. The responses of the functional type 2A-REL-Sp and corresponding taxa predict post-COVID-19 environmental concerns and the bioaccumulation of ivermectin in seafoods.</AbstractText><CopyrightInformation>Copyright © 2020 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Essid</LastName><ForeName>Naceur</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>University of Carthage, Faculty of Sciences of Bizerte, Laboratory of Environment Biomonitoring, Coastal Ecology and Ecotoxicology Unit, 7021 Zarzouna, Tunisia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Allouche</LastName><ForeName>Mohamed</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>University of Carthage, Faculty of Sciences of Bizerte, Laboratory of Environment Biomonitoring, Coastal Ecology and Ecotoxicology Unit, 7021 Zarzouna, Tunisia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lazzem</LastName><ForeName>Mounira</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>University of Carthage, Faculty of Sciences of Bizerte, Laboratory of Environment Biomonitoring, Coastal Ecology and Ecotoxicology Unit, 7021 Zarzouna, Tunisia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Harrath</LastName><ForeName>Abdel Halim</ForeName><Initials>AH</Initials><AffiliationInfo><Affiliation>King Saud University, Zoology Department, College of Science, Box 2455, Riyadh 11451, Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mansour</LastName><ForeName>Lamjed</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>King Saud University, Zoology Department, College of Science, Box 2455, Riyadh 11451, Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Alwasel</LastName><ForeName>Saleh</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>King Saud University, Zoology Department, College of Science, Box 2455, Riyadh 11451, Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mahmoudi</LastName><ForeName>Ezzeddine</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>University of Carthage, Faculty of Sciences of Bizerte, Laboratory of Environment Biomonitoring, Coastal Ecology and Ecotoxicology Unit, 7021 Zarzouna, Tunisia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Beyrem</LastName><ForeName>Hamouda</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>University of Carthage, Faculty of Sciences of Bizerte, Laboratory of Environment Biomonitoring, Coastal Ecology and Ecotoxicology Unit, 7021 Zarzouna, Tunisia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Boufahja</LastName><ForeName>Fehmi</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>University of Carthage, Faculty of Sciences of Bizerte, Laboratory of Environment Biomonitoring, Coastal Ecology and Ecotoxicology Unit, 7021 Zarzouna, Tunisia. Electronic address: fehmiboufahja@yahoo.fr.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>06</Month><Day>11</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Mar Pollut Bull</MedlineTA><NlmUniqueID>0260231</NlmUniqueID><ISSNLinking>0025-326X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>70288-86-7</RegistryNumber><NameOfSubstance UI="D007559">Ivermectin</NameOfSubstance></Chemical></ChemicalList><SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName><SupplMeshName Type="Protocol" UI="C000705127">COVID-19 drug treatment</SupplMeshName><SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName></SupplMeshList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000998" MajorTopicYN="N">Antiviral Agents</DescriptorName><QualifierName UI="Q000633" MajorTopicYN="Y">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="N">Betacoronavirus</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="Y">Coronavirus Infections</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005602" MajorTopicYN="N" Type="Geographic">France</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007558" MajorTopicYN="N" Type="Geographic">Italy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007559" MajorTopicYN="Y">Ivermectin</DescriptorName><QualifierName UI="Q000633" MajorTopicYN="N">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008522" MajorTopicYN="N" Type="Geographic">Mediterranean Sea</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009348" MajorTopicYN="Y">Nematoda</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="Y">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011024" MajorTopicYN="Y">Pneumonia, Viral</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013030" MajorTopicYN="N" Type="Geographic">Spain</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">COVID-19</Keyword><Keyword MajorTopicYN="N">Ecotoxicity</Keyword><Keyword MajorTopicYN="N">Ivermectin</Keyword><Keyword MajorTopicYN="N">Meiobenthic nematodes</Keyword></KeywordList><CoiStatement>Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>05</Month><Day>05</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>06</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>7</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>7</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>7</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId 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sortKey="Boufahja, Fehmi" sort="Boufahja, Fehmi" uniqKey="Boufahja F" first="Fehmi" last="Boufahja">Fehmi Boufahja</name><name sortKey="Lazzem, Mounira" sort="Lazzem, Mounira" uniqKey="Lazzem M" first="Mounira" last="Lazzem">Mounira Lazzem</name><name sortKey="Mahmoudi, Ezzeddine" sort="Mahmoudi, Ezzeddine" uniqKey="Mahmoudi E" first="Ezzeddine" last="Mahmoudi">Ezzeddine Mahmoudi</name></country><country name="Arabie saoudite"><noRegion><name sortKey="Harrath, Abdel Halim" sort="Harrath, Abdel Halim" uniqKey="Harrath A" first="Abdel Halim" last="Harrath">Abdel Halim Harrath</name></noRegion><name sortKey="Alwasel, Saleh" sort="Alwasel, Saleh" uniqKey="Alwasel S" first="Saleh" last="Alwasel">Saleh Alwasel</name><name sortKey="Mansour, Lamjed" sort="Mansour, Lamjed" uniqKey="Mansour L" first="Lamjed" last="Mansour">Lamjed Mansour</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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